What is a GLP-1 agonist?
A class of drugs (semaglutide, tirzepatide) that mimic a gut hormone tied to appetite.
A GLP-1 agonist is a type of drug that mimics GLP-1, a hormone the gut releases that is tied to appetite and blood sugar. Semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) are the best known examples.
'Agonist' just means something that switches on a receptor, so a GLP-1 agonist activates the same receptors the natural hormone would. That is the mechanism people point to when they talk about GLP-1s for weight and appetite.
TRKD+ explains what the class is and how people discuss it, and leaves recommending or prescribing to a licensed provider.
Common questions
People also ask.
- Are semaglutide and tirzepatide GLP-1 agonists?
- Semaglutide is a GLP-1 agonist. Tirzepatide activates both GLP-1 and GIP receptors, so it is often called a dual agonist.
- What does agonist mean?
- An agonist is something that activates a receptor to produce a response, here the GLP-1 receptor.
Related terms
Keep reading.
- Protocol
Peptide
A short chain of amino acids. Smaller than a protein, larger than a single amino acid.
- Timing
Half-life
How long it takes for half of a dose to clear your system. Drives dosing frequency.
- Protocol
Titration
Easing a dose up or down gradually over weeks, rather than jumping straight to a target.
TRKD+
Track the whole stack, calmly.
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